Could Lipoprotein Lipase Play a Role in Alzheimer's Disease?
نویسندگان
چکیده
منابع مشابه
Lipoprotein Lipase (LPL) Gene Mutation: A First Report in Children
Genetic hyperchylomicronemia is a rare autosomal recessive disorder of lipoprotein metabolism estimated to affect approximately one per million individuals. We report a case with a rare mutation identified. It’s a genetic chylomicronemia in a Moroccan newborn baby, with massive hypertriglyceridemia and clinical signs of acute pancreatitis. She was a newborn female, first-degree of consanguineou...
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Humans and animals deficient in lipoprotein lipase (EC 3.1.1.34; LPL) develop a massive hypertriacylglycerolaemia (Brunzell, 1995). Hence, LPL-mediated hydrolysis of lipoprotein-triacylglycerols is a necessary step in lipoprotein metabolism. The reaction occurs at ‘binding-lipolysis’ sites at the vascular endothelium (Olivecrona & Olivecrona, 1995). Here the enzyme is anchored by interaction wi...
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Whilst effective antiretroviral therapy is protective against the more severe forms of HIV-associated brain disease, there remains a large burden of clinically symptomatic cognitive impairment in the modern era. Although several potential pathogenic mechanisms have been proposed, the underlying pathology remains elusive. In this review, we summarize the evidence describing neuronal toxicity of ...
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Background: The low density lipoprotein cholestrol (LDL-C) has an important role in the pathogenesis of cardiovascular disease but its association and predictive accuracy with metabolic syndrome (MetS) remains controversial. The objective of this study was to investigate the association and predictive ability of LDL-C with MetS. Methods: We analyzed the data from a population-based cross-secti...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2004
ISSN: 1537-744X
DOI: 10.1100/tsw.2004.111